GSK 951A ( GSK951A;GSK-951A )

Catalog No. M11687 CAS No. 1403602-33-4

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Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK 951A
Note

Research use only, not for human use.
Brief Description

A small molecule with bactericidal efficacy against Mycobacterium tuberculosis with H37Rv MIC of 0.16 uM.
Description

A small molecule with bactericidal efficacy against Mycobacterium tuberculosis with H37Rv MIC of 0.16 uM; suppresses mycolic acid synthesis and EchA6 is essential, and are bactericidal in mouse model of chronic tuberculosis infection.
Synonyms

GSK951A;GSK-951A
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

1403602-33-4
Formula Weight

472.47
Molecular Formula

C24H23F3N4O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=C2N[C@@H](C3=CC=C(CC)C=C3)C[C@@H](C(F)(F)F)N2N=C1)NCC4=C5OCOC5=CC=C4
Chemical Name

(5R,7S)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

1. Cox JA, et al. Nat Microbiol. 2016 Jan 18;1:15006.
2. Remuián MJ, et al. PLoS One. 2013 Apr 17;8(4):e60933.

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